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Article

MRI-Based Genetic Studies Reveal Specific Genetic Variants and Disease Risks Associated With Fat Distribution Across Anatomical Sites.

Journal of obesity - 1 Jan 2025

Ahmed Altayeb, Cule Madeleine, Naz Afreen, Thanaj Marjola, Sorokin Elena P, Odoemelam Chiemela S, Whitcher Brandon, Sattar Naveed, Bell Jimmy D, Thomas E Louise, Yaghootkar Hanieh

Abstract excerpt

Objective: To investigate the genetic determinants of fat distribution across anatomical sites and their implications for health outcomes. Methods: We analyzed neck-to-knee MRI data from the UK Biobank (n = 37,589) to measure fat at various locations and used Mendelian randomization to assess effects on 26 obesity-related diseases and 94 biomarkers from FinnGen and other consortia. Result: We identified genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40922984
DOI: 10.1155/jobe/7792701
PMCID: PMC12414625

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