Article
Deep learning and genome-wide association meta-analyses of bone marrow adiposity in the UK Biobank.
Nature communications - 2 Jan 2025
Xu Wei, Mesa-Eguiagaray Ines, Morris David M, Wang Chengjia, Gray Calum D, Sjöström Samuel, Papanastasiou Giorgos, Badr Sammy, Paccou Julien, Li Xue, Timmers Paul R H J, Timofeeva Maria, Farrington Susan M, Dunlop Malcolm G, Semple Scott I, MacGillivray Tom, Theodoratou Evropi, Cawthorn William P
Abstract excerpt
Bone marrow adipose tissue is a distinct adipose subtype comprising more than 10% of fat mass in healthy humans. However, the functions and pathophysiological correlates of this tissue are unclear, and its genetic determinants remain unknown. Here, we use deep learning to measure bone marrow adiposity in the femoral head, total hip, femoral diaphysis, and spine from MRI scans of approximately 47,000 UK Biobank...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.