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Genetic architecture of bone marrow fat fraction implies its involvement in osteoporosis risk

12 Aug 2025

Abstract excerpt

Bone marrow adipose tissue, as a distinct adipose subtype, has been implicated in the pathophysiology of skeletal, metabolic, and hematopoietic disorders. To identify its underlying genetic factors, we utilized a deep learning algorithm capable of quantifying bone marrow fat fraction (BMFF) in the vertebrae and proximal femur using magnetic resonance imaging data of over 38,000 UK Biobank participants....

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PMID: 40796918
DOI: 10.1038/s41467-025-62826-3

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