Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

LPS induces RGS-1 to promote infectious intracranial aneurysm formation and rupture by accelerating smooth muscle cell phenotypic switching.

International immunopharmacology - 5 Dec 2024

Hu Xingwei, He Xiang, Zhang Wei, Jin Caide, Deng Chancui, Ma Yi, Chen Panke, Ma Shuai, Zhao Ranzun, Shi Bei

Abstract excerpt

OBJECTIVE: Patients with infectious intracranial aneurysms (IIAs) have high mortality rates. Sepsis is an important condition that induces IIA. Smooth muscle cell (SMC) phenotypic switching may have a critical effect on sepsis-induced IIA, but its role remains unclear. Hence, we aimed to identify sepsis-induced target genes involved in SMC phenotypic switching and their underlying mechanisms. METHODS AND RESULTS:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Proliferation
Share to Cells, Cultured

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intracranial Aneurysm

Share to Lipopolysaccharides

Share to Myocytes, Smooth Muscle

Share to RGS Proteins

Share to Sepsis

Share to STAT1 Transcription Factor

Source

Identifiers

PMID: 39312859
DOI: 10.1016/j.intimp.2024.113203

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

LPS induces RGS-1 to promote infectious intracranial aneurysm formation and rupture by accelerating smooth muscle cell phenotypic switching.PMID 39312859Read ↗

Vascular smooth muscle cells in intracranial aneurysms.Semantic proximity Read ↗

HMGB1 promotes intracranial aneurysm progression by regulating vascular smooth muscle cell phenotypic switching and ferroptosis.Semantic proximity Read ↗

CircGNAQ Promotes Intracranial Aneurysm Formation by Facilitating Vascular Smooth Muscle Cell Phenotypic Switching and Apoptosis.Semantic proximity Read ↗

Comprehensive analysis of mitochondrial dysfunction and necroptosis in intracranial aneurysms from the perspective of predictive, preventative, and personalized medicineSemantic proximity Read ↗

Inflammatory Responses Induced by the Rupture of Intracranial Aneurysms Are Modulated by miRNAsSemantic proximity Read ↗

Phenotypic transformation of smooth muscle in vasospasm after aneurysmal subarachnoid hemorrhage.Semantic proximity Read ↗

Single-cell transcriptome analysis reveals the cellular atlas of human intracranial aneurysm and highlights inflammation features associated with aneurysm ruptureSemantic proximity Read ↗

Decoding the biology and clinical implication of neutrophils in intracranial aneurysmSemantic proximity Read ↗

Phosphorylated NPY1R regulates phenotypic transition of vascular smooth muscle cells, inflammatory response and macrophage infiltration to promote intracranial aneurysm progression.Semantic proximity Read ↗

Comprehensive Analysis of Endoplasmic Reticulum Stress in Intracranial AneurysmSemantic proximity Read ↗

Deciphering the Intercellular Communication Between Immune Cells and Altered Vascular Smooth Muscle Cell Phenotypes in Aortic Aneurysm From Single-Cell Transcriptome DataSemantic proximity Read ↗

Intracranial Aneurysm as a Macrophage-mediated Inflammatory DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.