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Integrative analysis of single-cell sequencing, bulk transcriptomics and experimental verification reveals key molecular mechanisms of vascular smooth muscle cells involved in intracranial aneurysm progression

2026-04-08

Abstract excerpt

<title>Abstract</title> <p>Background and Purpose Intracranial aneurysm (IA) represents a prevalent cerebrovascular disorder. Although VSMC dysfunction has been implicated as a central contributor to IA pathogenesis, the precise molecular underpinnings remain incompletely elucidated. This study sought to leverage multi-omics integration for characterizing VSMC-associated pivotal genes and their upstream regulato...

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Literature Corpus work
f2e65c8a-f831-5ff8-acd2-cc9e5888a3c2
DOI
10.21203/rs.3.rs-9028687/v1
Open publication

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Integrative analysis of single-cell sequencing, bulk transcriptomics and experimental verification reveals key molecular mechanisms of vascular smooth muscle cells involved in intracranial aneurysm progressionDOI 10.21203/rs.3.rs-9028687/v1
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