Exploring variation in the d(N)/d(S) ratio among sites and lineages using mutational mappings: applications to the influenza virus.

Abstract excerpt

We use a likelihood-based method for mapping mutations on a phylogeny in a way that allows for both site-specific and lineage-specific variation in selection intensity. The method accounts for many of the potential sources of bias encountered in mapping of mutations on trees while still being computationally efficient. We apply the method to a previously published influenza data set to investigate hypotheses...

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