Article
Machine learning discriminates a movement disorder in a zebrafish model of Parkinson's disease.
Disease models & mechanisms - 16 Oct 2020
Hughes Gideon L, Lones Michael A, Bedder Matthew, Currie Peter D, Smith Stephen L, Pownall Mary Elizabeth
Abstract excerpt
Animal models of human disease provide an in vivo system that can reveal molecular mechanisms by which mutations cause pathology, and, moreover, have the potential to provide a valuable tool for drug development. Here, we have developed a zebrafish model of Parkinson's disease (PD) together with a novel method to screen for movement disorders in adult fish, pioneering a more efficient drug-testing route. Mutation...
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