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Article

Diffuse Midline Gliomas with Histone H3-K27M Mutation: A Series of 47 Cases Assessing the Spectrum of Morphologic Variation and Associated Genetic Alterations.

Brain pathology (Zurich, Switzerland) - 1 Sept 2016

Solomon David A, Wood Matthew D, Tihan Tarik, Bollen Andrew W, Gupta Nalin, Phillips Joanna J J, Perry Arie

Abstract excerpt

Somatic mutations of the H3F3A and HIST1H3B genes encoding the histone H3 variants, H3.3 and H3.1, were recently identified in high-grade gliomas arising in the thalamus, pons and spinal cord of children and young adults. However, the complete range of patients and locations in which these tumors arise, as well as the morphologic spectrum and associated genetic alterations remain undefined. Here, we describe a...

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Identifiers

PMID: 26517431
DOI: 10.1111/bpa.12336
PMCID: PMC6055926

Genes

ATRX
BRAF
EGFR
IDH1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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