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Article

MRI and Molecular Characterization of Pediatric High-Grade Midline Thalamic Gliomas: The HERBY Phase II Trial.

Radiology - 1 Jul 2022

Rodriguez Daniel, Calmon Raphael, Aliaga Esther Sanchez, Warren Daniel, Warmuth-Metz Monika, Jones Chris, Mackay Alan, Varlet Pascale, Le Deley Marie-Cécile, Hargrave Darren, Cañete Adela, Massimino Maura, Azizi Amedeo A, Saran Frank, Zahlmann Gudrun, Garcia Josep, Vassal Gilles, Grill Jacques, Peet Andrew, Dineen Robert A, Morgan Paul S, Jaspan Timothy

Abstract excerpt

Background Diffuse midline gliomas (DMG) are characterized by a high incidence of H3 K27 mutations and poorer outcome. The HERBY trial has provided one of the largest cohorts of pediatric DMGs with available radiologic, histologic-genotypic, and survival data. Purpose To define MRI and molecular characteristics of DMG. Materials and Methods This study is a secondary analysis of a prospective trial (HERBY;...

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PMID: 35412366
DOI: 10.1148/radiol.211464

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