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Article

Bacillus subtilis σA and Escherichia coli σ70 lacking σ region 1.1 are not released during transcription initiation and elongation.

Proceedings of the National Academy of Sciences of the United States of America - 23 Sept 2025

Tewary Aniruddha, Sengupta Shreya, Mukherjee Soumya, Hazra Nilanjana, Ebright Yon W, Ebright Richard H, Mukhopadhyay Jayanta

Abstract excerpt

A "σ cycle" in which the initiation factor σ associates with RNA polymerase (RNAP) core enzyme to permit transcription initiation and dissociates from RNAP core enzyme to permit transcription elongation, has been proposed to occur and to be an essential step for σ-exchange, with all principal σ factors from all bacteria. These proposals were based on studies of the principal σ factor of Escherichia coli, σ70,...

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Identifiers

PMID: 40961149
DOI: 10.1073/pnas.2503801122
PMCID: PMC12478191

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