Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A mutation in region 1.1 of sigma70 affects promoter DNA binding by Escherichia coli RNA polymerase holoenzyme.

The EMBO journal - 1 Feb 1999

Bowers C W, Dombroski A J

Abstract excerpt

The sigma subunit of eubacterial RNA polymerase is essential for initiation of transcription at promoter sites. It directs recognition of DNA sequences by holoenzyme (alpha2betabeta'sigma) and facilitates subsequent steps in the initiation pathway. The primary sigma factor from Escherichia coli, sigma70, has four regions that are conserved among members of the sigma70 family. Previous work has shown that region...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to DNA, Bacterial
Share to Escherichia coli

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Phenotype

Share to Point Mutation

Share to Promoter Regions, Genetic

Share to Suppression, Genetic

Share to Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 9927430
DOI: 10.1093/emboj/18.3.709
PMCID: PMC1171163

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A mutation in region 1.1 of sigma70 affects promoter DNA binding by Escherichia coli RNA polymerase holoenzyme.PMID 9927430Read ↗

Isolation and characterization of mutations in region 1.2 of Escherichia coli sigma70.Semantic proximity Read ↗

Mutant forms of Salmonella typhimurium sigma54 defective in transcription initiation but not promoter binding activity.Semantic proximity Read ↗

Mutations in the 1.1 subdomain of Escherichia coli sigma factor sigma70 and disruption of its overall structure.Semantic proximity Read ↗

In vitro roles of invariant helix-turn-helix motif residue R383 in sigma(54) (sigma(N)).Semantic proximity Read ↗

Converting Escherichia coli RNA polymerase into an enhancer-responsive enzyme: role of an NH2-terminal leucine patch in sigma 54.Semantic proximity Read ↗

X-ray crystal structure of Escherichia coli RNA polymerase σ70 holoenzyme.Semantic proximity Read ↗

Interactions of regulated and deregulated forms of the sigma54 holoenzyme with heteroduplex promoter DNA.Semantic proximity Read ↗

Sequences within the DNA cross-linking patch of sigma 54 involved in promoter recognition, sigma isomerization, and open complex formation.Semantic proximity Read ↗

On the role of the Escherichia coli RNA polymerase sigma 70 region 4.2 and alpha-subunit C-terminal domains in promoter complex formation on the extended -10 galP1 promoter.Semantic proximity Read ↗

Substitutions in the Escherichia coli RNA polymerase sigma70 factor that affect recognition of extended -10 elements at promoters.Semantic proximity Read ↗

Bacillus subtilis σA and Escherichia coli σ70 lacking σ region 1.1 are not released during transcription initiation and elongation.Semantic proximity Read ↗

Crystal structure of a sigma 70 subunit fragment from E. coli RNA polymerase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.