A mutation in region 1.1 of sigma70 affects promoter DNA binding by Escherichia coli RNA polymerase holoenzyme.

doi:10.1093/emboj/18.3.709

Back to search

Article

A mutation in region 1.1 of sigma70 affects promoter DNA binding by Escherichia coli RNA polymerase holoenzyme.

The EMBO journal - 1 Feb 1999

Bowers C W, Dombroski A J

Abstract excerpt

The sigma subunit of eubacterial RNA polymerase is essential for initiation of transcription at promoter sites. It directs recognition of DNA sequences by holoenzyme (alpha2betabeta'sigma) and facilitates subsequent steps in the initiation pathway. The primary sigma factor from Escherichia coli,...

Topics

Amino Acid Substitution
Catalytic Domain
DNA, Bacterial
DNA-Directed RNA Polymerases
Escherichia coli
Holoenzymes
Phenotype
Point Mutation
Promoter Regions, Genetic
Sigma Factor
Suppression, Genetic
Transcription, Genetic

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.