Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polygenic risk score of Alzheimer's disease is associated with cognitive trajectories and phenotypes of cerebral organoids.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Sept 2025

Chun Min Young, Jung Sang-Hyuk, Choe Juran, Lee Seung-Yeon, Kim Hang-Rai, Son Hyo Jin, Choi Yejoo, Cho Minyoung, Kim Beomsu, Jang Hyemin, Choi Seong Hye, Jeong Jee Hyang, Son Sang Joon, Hong Chang Hyung, Roh Hyun Woong, Na Duk L, Seo Sang Won, Won Hong-Hee, Seo Jinsoo, Kim Hee Jin

Abstract excerpt

INTRODUCTION: Polygenic risk score (PRS) identifies individuals at high genetic risk for Alzheimer's disease (AD), but its utility in predicting cognitive trajectories and AD pathologies remains unclear. We optimized PRS (optPRS) for AD, investigated its association with cognitive trajectories and AD phenotypes of cerebral organoids. METHODS: Using genome-wide association study (GWAS) summary statistics from a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Peptides
Share to Cognition

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cognitive Dysfunction

Share to Genetic Risk Score

Share to Induced Pluripotent Stem Cells

Share to Multifactorial Inheritance

Share to Organoids

Share to tau Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 40959898
DOI: 10.1002/alz.70660
PMCID: PMC12441735

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polygenic risk score of Alzheimer's disease is associated with cognitive trajectories and phenotypes of cerebral organoids.PMID 40959898Read ↗

Endophenotype-based polygenic risk scores: Prediction of biomarker and clinical progression and dementiaSemantic proximity Read ↗

A/T/N polygenic risk score for cognitive decline in old ageSemantic proximity Read ↗

From Polygenic Scores to Precision Medicine in Alzheimer's Disease: A Systematic Review.Semantic proximity Read ↗

Modeling common Alzheimer’s disease with high and low polygenic risk in human iPSC: A large-scale research resourceSemantic proximity Read ↗

Polygenic Risk Score Reveals Genetic Heterogeneity of Alzheimer's Disease between the Chinese and European Populations.Semantic proximity Read ↗

Association of polygenic risk scores with Alzheimer's disease and plasma biomarkers among Chinese older adults: A community-based study.Semantic proximity Read ↗

NEUBOrg: artificially induced pluripotent stem cell-derived brain organoid to model and study genetics of Alzheimer’s disease progression.Semantic proximity Read ↗

Pathway-Specific Polygenic Risk Scores Correlate with Clinical Status and Alzheimer's Disease-Related Biomarkers.Semantic proximity Read ↗

Polygenic score integrating neurodegenerative and vascular risk informs dementia risk stratification.Semantic proximity Read ↗

Polygenic Risk Scores in Alzheimer's Disease Genetics: Methodology, Applications, Inclusion, and Diversity.Semantic proximity Read ↗

Cell-type-specific Alzheimer’s disease polygenic risk scores are associated with distinct disease processes in Alzheimer’s diseaseSemantic proximity Read ↗

Pathway-specific polygenic risk scores correlate with clinical status and Alzheimer’s-related biomarkersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.