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Modeling common Alzheimer’s disease with high and low polygenic risk in human iPSC: A large-scale research resource

3 Jul 2025

Abstract excerpt

Common forms of Alzheimer's disease (AD) are complex and polygenic. We have created a research resource that seeks to capture the extremes of polygenic risk in a collection of human induced pluripotent stem cell (iPSC) lines from over 100 donors: the IPMAR Resource (iPSC Platform to Model Alzheimer's Disease Risk). Donors were selected from a large UK cohort of 6,000+ research-diagnosed early or late-onset AD...

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PMID: 40614728
DOI: 10.1016/j.stemcr.2025.102570

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