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Article

Uncovering potential drug targets for lactylation-related genes mediated intervertebral disc degeneration: A Mendelian randomization analysis integrating eQTL data.

Medicine - 12 Sept 2025

Yang Yang, Liu Dingxuan, Ai Zhen, Gao Xi

Abstract excerpt

Intervertebral disc degeneration (IVDD) is a common cause of neck, back, and low back pain, it is also a major global public health problem. Lactate is a metabolic product of intervertebral disc cells and is closely related to disc degeneration. Lactylation (Lac), driven by lactic acid, is associated with intervertebral disc degeneration, and targeting-related genes may provide new therapeutic directions for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40958296
DOI: 10.1097/MD.0000000000044382
PMCID: PMC12440491

Genes

NDUFA13
NFU1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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