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Integrating Bulk RNA and Single‐Cell RNA Sequencing Identifies and Validates Lactylation‐Related Signatures for Intervertebral Disc Degeneration

1 Dec 2024

Abstract excerpt

Glycolysis-related lactylation has gained wide attention for regulating various cellular functions and diseases. Nevertheless, its intricate involvement in intervertebral disc degeneration (IVDD) is not yet fully understood. In this study, we unrevealed the intricate association between elevated lactylation levels and the development of IVDD. Subsequently, we harvested the lactylation-related genes (LRGs) and...

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PMID: 39636180
DOI: 10.1111/jcmm.70262

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