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Article

RNA editing underlies genetic risk of common inflammatory diseases.

Nature - 1 Aug 2022

Li Qin, Gloudemans Michael J, Geisinger Jonathan M, Fan Boming, Aguet François, Sun Tao, Ramaswami Gokul, Li Yang I, Ma Jin-Biao, Pritchard Jonathan K, Montgomery Stephen B, Li Jin Billy

Abstract excerpt

A major challenge in human genetics is to identify the molecular mechanisms of trait-associated and disease-associated variants. To achieve this, quantitative trait locus (QTL) mapping of genetic variants with intermediate molecular phenotypes such as gene expression and splicing have been widely adopted1,2. However, despite successes, the molecular basis for a considerable fraction of trait-associated and...

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Share to RNA, Double-Stranded
Share to Inosine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interferon-Induced Helicase, IFIH1

Share to Adenosine

Share to Adenosine Deaminase

Share to Alu Elements

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Source

Open in PubMed Open full text

Identifiers

PMID: 35922514
DOI: 10.1038/s41586-022-05052-x
PMCID: PMC9790998

Genes

ADAR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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