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Article

Differential Association of the DISC1 Interactome in Hallucinations and Delusions.

International journal of molecular sciences - 8 Sept 2025

Gutiérrez-Rodríguez Araceli, Genis-Mendoza Alma Delia, Villatoro-Velázquez Jorge Ameth, Medina-Mora María Elena, Nicolini Humberto

Abstract excerpt

Multiple genes within the DISC1 (Disrupted-in-Schizophrenia-1) interactome have been implicated in psychotic disorders, which are characterized by hallucinations, delusions, negative symptoms, and disorganized behavior. However, the genetic associations of specific psychotic symptoms remain poorly understood. METHODS: We conducted a genetic association analysis of the DISC1 interactome for hallucinations and...

Read the complete abstract on PubMed

Topics

Humans
Hallucinations
Nerve Tissue Proteins
Polymorphism, Single Nucleotide
Delusions
Schizophrenia

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Male

Bipolar Disorder

Female

Genetic Association Studies

Cell Adhesion Molecules, Neuronal

Adult

Neuregulin-1

Calcium-Binding Proteins

Neural Cell Adhesion Molecules

Source

Open in PubMed Open full text

Identifiers

PMID: 40943654
DOI: 10.3390/ijms26178738
PMCID: PMC12429122

Genes

NRXN1
DISC1
APP
EXOC4
NRG1
NUP210
PCM1
ZNF365

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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