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Article

A stronger type I interferon signature distinguishes ANCA-associated vasculitis phenotypes and predicts kidney prognosis.

Kidney international - 1 Jan 2026

Brilland Benoît, Despré Maïa, Khatri Robin, Quéméneur Thomas, Vandenbussche Cyrille, Merillon Nathalie, Boizard-Moracchini Andrea, Roy Maëva, Preisser Laurence, Riou Jérémie, Piccoli Giorgina Barbara, Djema Assia, Henry Nicolas, Blanchet Odile, Bonn Stefan, Berthier Céline C, Grayson Peter, Delneste Yves, Gnemmi Viviane, Blanco Patrick, Copin Marie-Christine, Langlais David, Augusto Jean-François

Abstract excerpt

INTRODUCTION: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) causes severe multisystemic organ damage. The main phenotypes, microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA), share similarities but differ in clinical presentation and outcome. To uncover their molecular differences, we performed transcriptomic profiling of kidney tissue, then focused on type I...

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Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Dendritic Cells
Glomerulonephritis
Granulomatosis with Polyangiitis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interferon Type I

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Identifiers

PMID: 40935134
DOI: 10.1016/j.kint.2025.07.034
PMCID: PMC13245454

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MPO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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