Article
Managing differential performance of polygenic risk scores across groups: Real-world experience of the eMERGE Network.
American journal of human genetics - 6 Jun 2024
Lewis Anna C F, Chisholm Rex L, Connolly John J, Esplin Edward D, Glessner Joe, Gordon Adam, Green Robert C, Hakonarson Hakon, Harr Margaret, Holm Ingrid A, Jarvik Gail P, Karlson Elizabeth, Kenny Eimear E, Kottyan Leah, Lennon Niall, Linder Jodell E, Luo Yuan, Martin Lisa J, Perez Emma, Puckelwartz Megan J, Rasmussen-Torvik Laura J, Sabatello Maya, Sharp Richard R, Smoller Jordan W, Sterling Rene, Terek Shannon, Wei Wei-Qi, Fullerton Stephanie M
Abstract excerpt
The differential performance of polygenic risk scores (PRSs) by group is one of the major ethical barriers to their clinical use. It is also one of the main practical challenges for any implementation effort. The social repercussions of how people are grouped in PRS research must be considered in communications with research participants, including return of results. Here, we outline the decisions faced and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.