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Article

Healthcare professionals' experiences returning monogenic, polygenic, and integrated risk results in the eMERGE study.

HGG advances - 15 Jan 2026

Suckiel Sabrina A, Golfinopoulos Laura, Scherr Courtney L, Boyd Brenna M, Chung Wendy K, Hakonarson Hakon, Holm Ingrid A, Kullo Iftikhar J, Limdi Nita A, Murray Michael F, Myers Melanie F, Prows Cynthia A, Sabatello Maya, Wiesner Georgia L, Kenny Eimear E, Abul-Husn Noura S

Abstract excerpt

Clinical interest in polygenic (PRS) and integrated (PRS plus clinical factors) risk scores (IRS) is growing, yet little data exist on how healthcare providers navigate returning these results to patients. The eMERGE IV study implemented a genome-informed risk assessment for 11 common complex conditions, incorporating PRS, IRS, and monogenic findings, offering an opportunity to examine providers' experiences...

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Identifiers

PMID: 41353565
DOI: 10.1016/j.xhgg.2025.100554
PMCID: PMC12799777

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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