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Article

Pharmacogenomic insights into atorvastatin and rosuvastatin adverse effects: a prospective observational study in the UAE's multiethnic population.

Human genomics - 25 Apr 2025

Alqasrawi Mais N, Al-Mahayri Zeina N, AlBawa'neh Areej S, Khasawneh Lubna Q, Dabaghie Lilas, Altoum Sahar M, Hamza Dana, Misra Virendra, Ouda Husam, Aburuz Salahdein, Al-Maskari Fatima, AlKaabi Juma, Patrinos George P, Ali Bassam R

Abstract excerpt

BACKGROUND: Statins are essential for managing cardiovascular disease (CVD), but adverse effects often lead to treatment discontinuation and non-adherence, underscoring the need for personalized approaches. This study aimed to evaluate the influence of pharmacogenomic (PGx) variants and demographic factors on statin-associated adverse effects in a multiethnic cohort from the United Arab Emirates (UAE). METHODS:...

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Share to Atorvastatin
Share to ATP Binding Cassette Transporter, Subfamily G, Member 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Drug-Related Side Effects and Adverse Reactions

Share to Hydroxymethylglutaryl-CoA Reductase Inhibitors

Share to Liver-Specific Organic Anion Transporter 1

Share to Rosuvastatin Calcium

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Source

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Identifiers

PMID: 40281622
DOI: 10.1186/s40246-025-00753-6
PMCID: PMC12032684

Genes

ABCG2
SLCO1B1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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