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Loss of LasR function leads to decreased repression of <i>Pseudomonas aeruginosa</i> PhoB activity at physiological phosphate concentrations

2024-03-27

Abstract excerpt

While the Pseudomonas aeruginosa LasR transcription factor plays a role in quorum sensing (QS) across phylogenetically-distinct lineages, isolates with loss-of-function mutations in lasR (LasR– strains) are commonly found in diverse settings including infections where they are associated with worse clinical outcomes. In LasR– strains, the transcription factor RhlR, which is controlled by LasR, can be alternately...

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Literature Corpus work
4bc809a3-bdc4-594d-ba00-dde49ca1642c
DOI
10.1101/2024.03.27.586856
Open publication

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Loss of LasR function leads to decreased repression of <i>Pseudomonas aeruginosa</i> PhoB activity at physiological phosphate concentrationsDOI 10.1101/2024.03.27.586856
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