Loss of LasR function leads to decreased repression of Pseudomonas aeruginosa PhoB activity at physiological phosphate concentrations.

Abstract excerpt

The Pseudomonas aeruginosa LasR transcription factor plays a role in quorum sensing (QS) across phylogenetically distinct lineages. However, isolates with loss-of-function mutations in lasR (LasR- strains) are commonly found in diverse settings, including infections where they are associated with worse clinical outcomes. In LasR- strains, the LasR-regulated transcription factor RhlR can also be stimulated by the...

Topics

• Pseudomonas aeruginosa
• Bacterial Proteins
• Trans-Activators
• Phosphates
• Gene Expression Regulation, Bacterial
• Quorum Sensing