Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Malignant hyperthermia: a pharmacogenetic disease of Ca++ regulating proteins.

Current molecular medicine - 1 Jun 2002

Nelson Thomas E

Abstract excerpt

Malignant hyperthermia (MH) is a pharmacogenetic, life-threatening hypermetabolic syndrome in genetically predisposed individuals exposed to certain anesthetic agents. Discovered by Denborough and Lovell [1] in 1960, MH was associated with high mortality and morbidity as the cause was unknown and an effective treatment was unavailable. There is no classic clinical presentation of the syndrome, and the onset and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caffeine
Share to Calcium
Share to Dogs

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hydrogen-Ion Concentration

Share to Malignant Hyperthermia

Share to Muscle, Skeletal

Share to Ryanodine Receptor Calcium Release Channel

Source

Identifiers

PMID: 12108947
DOI: 10.2174/1566524023362429

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Malignant hyperthermia: a pharmacogenetic disease of Ca++ regulating proteins.PMID 12108947Read ↗

Malignant hyperthermia: a pharmacogenetic disorder.Semantic proximity Read ↗

Genetics and pathogenesis of malignant hyperthermiaSemantic proximity Read ↗

Malignant hyperthermia: an inherited disorder of skeletal muscle Ca+ regulation.Semantic proximity Read ↗

Malignant hyperthermia and associated disorders.Semantic proximity Read ↗

Malignant hyperthermia.Semantic proximity Read ↗

Dynamic alterations in myoplasmic Ca2+ in malignant hyperthermia and central core disease.Semantic proximity Read ↗

Clinical and Genetic Characterization of a Novel RYR1 Variant (p.Gln474His) in Malignant Hyperthermia Susceptibility.Semantic proximity Read ↗

Functional analysis of RYR1 variants in Australian and New Zealand patients at risk of susceptibility to malignant hyperthermia.Semantic proximity Read ↗

Malignant hyperthermia.Semantic proximity Read ↗

Advances in malignant hyperthermia: novel insights into heat-induced Ca2+ release as a thermal signaling.Semantic proximity Read ↗

Functional characterization of malignant hyperthermia-associated RyR1 mutations in exon 44, using the human myotube model.Semantic proximity Read ↗

Malignant HyperthermiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.