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Pathogenic CaV1.1 Variants Cause Hyperpolarizing Shift of Depolarization-Induced Ca2+ Release in Malignant Hyperthermia Susceptibility.

Communications biology - 29 May 2026

Murayama Takashi, Numaga-Tomita Takuro, Miyoshi Hirotsugu, Ikeda Tsuyoshi, Mukaida Keiko, Kobayashi Takuya, Kurebayashi Nagomi, Nakada Tsutomu, Tomida Taichiro, Adachi-Akahane Satomi, Tsutsumi Yasuo M, Yamada Mitsuhiko, Sakurai Takashi

Abstract excerpt

Malignant hyperthermia (MH) is a potentially fatal genetic disorder triggered by certain anesthetics, leading to excessive calcium release in skeletal muscle. While most MH-associated mutations affect the type 1 ryanodine receptor, a Ca2+ release channel in the sarcoplasmic reticulum, variants in CaV1.1-the L-type calcium channel critical for excitation-contraction coupling-have also been implicated. Here, we...

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Identifiers

PMID: 42215694
DOI: 10.1038/s42003-026-10281-1
PMCID: PMC13221468

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