Article
Enhanced excitation-coupled calcium entry in myotubes is associated with expression of RyR1 malignant hyperthermia mutations.
The Journal of biological chemistry - 28 Dec 2007
Yang Tianzhong, Allen Paul D, Pessah Isaac N, Lopez Jose R
Abstract excerpt
Myotubes expressing wild type RyR1 (WT) or RyR1 with one of three malignant hyperthermia mutations R615C, R2163C, and T4826I (MH) were exposed sequentially to 60 mm KCl in Ca(2+)-replete and Ca(2+)-free external buffers (Ca+ and Ca-, respectively) with 3 min of rest between exposures. Although the maximal peak amplitude of the Ca(2+) transients during K(+) depolarization was similar for WT and MH in both external...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.