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Article

Mice with R2509C-RYR1 mutation exhibit dysfunctional Ca2+ dynamics in primary skeletal myocytes.

The Journal of general physiology - 7 Nov 2022

Tsuboi Yoshitaka, Oyama Kotaro, Kobirumaki-Shimozawa Fuyu, Murayama Takashi, Kurebayashi Nagomi, Tachibana Toshiaki, Manome Yoshinobu, Kikuchi Emi, Noguchi Satoru, Inoue Takayoshi, Inoue Yukiko U, Nishino Ichizo, Mori Shuichi, Ishida Ryosuke, Kagechika Hiroyuki, Suzuki Madoka, Fukuda Norio, Yamazawa Toshiko

Abstract excerpt

Type 1 ryanodine receptor (RYR1) is a Ca2+ release channel in the sarcoplasmic reticulum (SR) of the skeletal muscle and plays a critical role in excitation-contraction coupling. Mutations in RYR1 cause severe muscle diseases, such as malignant hyperthermia, a disorder of Ca2+-induced Ca2+ release (CICR) through RYR1 from the SR. We recently reported that volatile anesthetics induce malignant hyperthermia...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36200983
DOI: 10.1085/jgp.202213136
PMCID: PMC9546722

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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