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Article

Emerging views of OPTN (optineurin) function in the autophagic process associated with disease

30 Mar 2021

Abstract excerpt

Macroautophagy/autophagy is a highly conserved process in eukaryotic cells. It plays a critical role in cellular homeostasis by delivering cytoplasmic cargos to lysosomes for selective degradation. OPTN (optineurin), a well-recognized autophagy receptor, has received considerable attention due to its multiple roles in the autophagic process. OPTN is associated with many human disorders that are closely related to...

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PMID: 33783320
DOI: 10.1080/15548627.2021.1908722

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Emerging views of OPTN (optineurin) function in the autophagic process associated with diseasePMID 33783320Read ↗

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Role of Optineurin in the Mitochondrial Dysfunction: Potential Implications in Neurodegenerative Diseases and CancerSemantic proximity Read ↗

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OPTN translocates to an ATG9A-positive compartment to regulate innate immune signalling and cytokine secretionSemantic proximity Read ↗

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Dysfunction of Optineurin in Amyotrophic Lateral Sclerosis and Glaucoma.Semantic proximity Read ↗

Defects in autophagy caused by glaucoma-associated mutations in optineurin.Semantic proximity Read ↗

Altered Functions and Interactions of Glaucoma-Associated Mutants of Optineurin.Semantic proximity Read ↗

Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins.Semantic proximity Read ↗

Functional analysis of optineurin and some of its disease-associated mutants.Semantic proximity Read ↗

Mutations in the ubiquitin-binding domain of OPTN/optineurin interfere with autophagy-mediated degradation of misfolded proteins by a dominant-negative mechanism.Semantic proximity Read ↗

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