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Article

Functional analysis of optineurin and some of its disease-associated mutants.

IUBMB life - 1 Feb 2015

Bansal Megha, Swarup Ghanshyam, Balasubramanian Dorairajan

Abstract excerpt

Optineurin is a multifunctional protein involved in a variety of cellular functions such as protein trafficking by vesicles, autophagy, and signal transduction. Certain mutations in optineurin (gene OPTN) are associated with neurodegenerative diseases like glaucoma and amyotrophic lateral sclerosis (ALS). Optineurin is also seen in pathological structures present in several other neurodegenerative diseases. In...

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Source

Identifiers

PMID: 25855473
DOI: 10.1002/iub.1355

Genes

OPTN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Functional analysis of optineurin and some of its disease-associated mutants.PMID 25855473Read ↗

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Optineurin: A Coordinator of Membrane-Associated Cargo Trafficking and Autophagy.Semantic proximity Read ↗

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Optineurin and Its Mutants: Molecules Associated with Some Forms of GlaucomaSemantic proximity Read ↗

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Loss of optineurin in vivo results in elevated cell death and alters axonal trafficking dynamics.Semantic proximity Read ↗

Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins.Semantic proximity Read ↗

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