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Inflammatory mitochondrial signalling and viral mimicry in cancer

2 Sept 2025

Abstract excerpt

Endogenous transposable elements (TEs) are receiving increasing attention as potential targets to develop novel immunostimulatory strategies against cancer. Indeed, the defective epigenetic suppression of TEs in malignant cells offers a therapeutic window to enable their re-activation with at least some degree of selectivity. In line with this notion, multiple clinically employed epigenetic modifiers such as...

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PMID: 40898334
DOI: 10.1186/s12967-025-06931-3

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