Article
Molecular Pathways: At the Crossroads of Cancer Epigenetics and Immunotherapy.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Sept 2015
Maio Michele, Covre Alessia, Fratta Elisabetta, Di Giacomo Anna Maria, Taverna Pietro, Natali Pier Giorgio, Coral Sandra, Sigalotti Luca
Abstract excerpt
Epigenetic regulation allows heritably modulating gene expression profiles without modifying the primary sequence of gDNA. Under physiologic conditions, epigenetic patterns determine tissue-specific gene expression landscapes, gene imprinting, inactivation of chromosome X, and preservation of genomic stability. The most characterized mediators of epigenetic inheritance are gDNA methylation and histone...
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