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Proteogenomic Discovery of Novel Open Reading Frames With HLA Immune Presentation on Human β-Cells

2 Sept 2025

Abstract excerpt

Ribosome profiling (Ribo-seq) measures translational regulation and reveals novel or unannotated open reading frames (nuORFs) otherwise difficult to identify. Recent reports demonstrate that nuORFs regulate gene expression and immune recognition, highlighting their emerging biological roles. Pancreatic β-cells are critical for maintaining euglycemic conditions, and β-cell impairment contributes to diabetes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40896833
DOI: 10.2337/db24-0527

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