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Article

miR-342-5p promotes vascular smooth muscle cell phenotypic transition through a negative-feedback regulation of Notch signaling via targeting FOXO3.

Life sciences - 1 Aug 2023

Wen Ting, Duan Yanyan, Gao Dan, Zhang Xinxin, Zhang Xiaoyan, Liang Liang, Yang Ziyan, Zhang Peiran, Zhang Jiayulin, Sun Jiaxing, Feng Yixuan, Zheng Qijun, Han Hua, Yan Xianchun

Abstract excerpt

AIM: Under various pathological conditions such as cancer, vascular smooth muscle cells (vSMCs) transit their contractile phenotype into phenotype(s) characterized by proliferation and secretion, a process called vSMC phenotypic transition (vSMC-PT). Notch signaling regulates vSMC development and vSMC-PT. This study aims to elucidate how the Notch signal is regulated. MAIN METHODS: Gene-modified mice with a...

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PMID: 37270171
DOI: 10.1016/j.lfs.2023.121828

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