Explaining the stable coexistence of drug-resistant and -susceptible pathogens: the resistance acquisition purifying selection model.

Abstract excerpt

Drug resistance is a problem in many pathogens. While overall, levels of resistance have risen in recent decades, there are many examples where after an initial rise, levels of resistance have stabilized. The stable coexistence of resistance and susceptibility has proven hard to explain - in most evolutionary models, either resistance or susceptibility ultimately "wins" and takes over the population. Here, we...

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