Host population structure and treatment frequency maintain balancing selection on drug resistance

Abstract excerpt

It is a truism that antimicrobial drugs select for resistance, but explaining pathogen- and population-specific variation in patterns of resistance remains an open problem. Like other common commensals, Streptococcus pneumoniae has demonstrated persistent coexistence of drug-sensitive and drug-resistant strains. Theoretically, this outcome is unlikely. We modelled the dynamics of competing strains of S....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Antibiotic Use and Resistance
• Share to Antibiotics Pharmacokinetics and Efficacy
• Share to Pneumonia and Respiratory Infections