Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Intercellular signaling reinforces single-cell level phenotypic transitions and facilitates robust re-equilibrium of heterogeneous cancer cell populations.

Cell communication and signaling : CCS - 28 Aug 2025

Lopez Daniel, Tyson Darren R, Hong Tian

Abstract excerpt

BACKGROUND: Cancer cells within tumors exhibit a wide range of phenotypic states driven by non-genetic mechanisms, such as epithelial-to-mesenchymal transition (EMT), in addition to extensively studied genetic alterations. Conversions among cancer cell states can result in intratumoral heterogeneity which contributes to metastasis and development of drug resistance. However, mechanisms underlying the initiation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Communication
Share to Epithelial-Mesenchymal Transition

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasms

Share to Phenotype

Share to Signal Transduction

Share to Single-Cell Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 40877935
DOI: 10.1186/s12964-025-02405-7
PMCID: PMC12392621

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intercellular signaling reinforces single-cell level phenotypic transitions and facilitates robust re-equilibrium of heterogeneous cancer cell populations.PMID 40877935Read ↗

Multivalent state transitions shape the intratumoral composition of small cell lung carcinomaSemantic proximity Read ↗

An individualized causal framework for learning intercellular communication networks that define microenvironments of individual tumorsSemantic proximity Read ↗

A unifying framework disentangles genetic, epigenetic, and stochastic sources of drug-response variability in an <i>in vitro</i> model of tumor heterogeneitySemantic proximity Read ↗

Deconvoluting single-cell transcriptomics reveals cellular programs regulated by cell-cell communication in colorectal cancerSemantic proximity Read ↗

Communication Breakdown and Evolution of the Cancer CellSemantic proximity Read ↗

Topological signatures in regulatory network enable phenotypic heterogeneity in small cell lung cancerSemantic proximity Read ↗

Single-cell analysis reveals inter- and intratumour heterogeneity in metastatic breast cancerSemantic proximity Read ↗

Single-cell Analysis Reveals Inter- and Intratumour Heterogeneity in Metastatic Breast CancerSemantic proximity Read ↗

AAnet resolves a continuum of spatially-localized cell states to unveil tumor complexitySemantic proximity Read ↗

Topological signatures in regulatory network enable phenotypic heterogeneity in small cell lung cancer.Semantic proximity Read ↗

Mathematically mapping the network of cells in the tumor microenvironmentSemantic proximity Read ↗

Epithelial-mesenchymal plasticity: How have quantitative mathematical models helped improve our understanding?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.