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Article

Homing and invasiveness of MLL/ENL leukemic cells is regulated by MEF2C

8 Jul 2009

Abstract excerpt

Acute myelogenous leukemia is driven by leukemic stem cells (LSCs) generated by mutations that confer (or maintain) self-renewal potential coupled to an aberrant differentiation program. Using retroviral mutagenesis, we identified genes that generate LSCs in collaboration with genetic disruption of the gene encoding interferon response factor 8 (Irf8), which induces a myeloproliferation in vivo. Among the...

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Identifiers

PMID: 19584403
DOI: 10.1182/blood-2008-05-158196

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