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Article

Memory-biased CD8αα⁺ T cells show reduced abundance and phenotypic remodeling in SLE.

Immunologic research - 9 Mar 2026

Xiong Ziqi, Xue Tianyi, Zhou Shaowei, Liang Yuhan, He Junru, Wei Yajie, Gao Yiming, Sun Xiaochen, Liu Chen

Abstract excerpt

To characterize peripheral CD8αα⁺ T cells in systemic lupus erythematosus (SLE), evaluate their quantitative and phenotypic alterations, and examine associations with autoantibody profiles and inflammatory markers. Forty treatment-naïve SLE patients and 46 age- and sex-matched healthy controls were recruited. Peripheral blood mononuclear cells were analyzed by flow cytometry to quantify CD8αα⁺ and CD8αβ⁺ T-cell...

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Share to Autoantibodies
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lupus Erythematosus, Systemic

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Source

Identifiers

PMID: 41801506
DOI: 10.1007/s12026-026-09759-1

Genes

CD28
GZMB
CCR7
CD27

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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