Article
Human Bone Marrow-Resident Natural Killer Cells Have a Unique Transcriptional Profile and Resemble Resident Memory CD8+ T Cells.
Frontiers in immunology - 1 Jan 2018
Melsen Janine E, Lugthart Gertjan, Vervat Carly, Kielbasa Szymon M, van der Zeeuw Sander A J, Buermans Henk P J, van Ostaijen-Ten Dam Monique M, Lankester Arjan C, Schilham Marco W
Abstract excerpt
Human lymphoid tissues harbor, in addition to CD56bright and CD56dim natural killer (NK) cells, a third NK cell population: CD69+CXCR6+ lymphoid tissue (lt)NK cells. The function and development of ltNK cells remain poorly understood. In this study, we performed RNA sequencing on the three NK cell populations derived from bone marrow (BM) and blood. In ltNK cells, 1,353 genes were differentially expressed...
Topics
- Biomarkers
- Bone Marrow Cells
- CD8-Positive T-Lymphocytes
- Computational Biology
- Cytotoxicity, Immunologic
- Gene Expression Profiling
- Humans
- Immunologic Memory
- Immunophenotyping