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Article

Effects of the genetic polymorphisms of TAS2R43 and TAS2R46 on receptors' function and on perceived bitterness of caffeine by human subjects.

Chemical senses - 22 Jan 2025

Numabe Rena, Rainish Alon, Niv Masha Y, Imai Hiroo

Abstract excerpt

We investigated the effects of coding single-nucleotide polymorphisms (SNPs) in bitter taste receptors TAS2R43 and TAS2R46 on their predicted structural stability, cellular functions, and human threshold for bitterness of caffeine. We found differences in the cell surface expression and reaction to caffeine among the haplotypes of TAS2R43 and -46 protein. Ancestral haplotypes of the proteins showed higher...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40856061
DOI: 10.1093/chemse/bjaf027

Genes

TAS2R43
TAS2R46

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