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Article

Single-Nucleotide Polymorphisms of TAS2R46 Affect the Receptor Downstream Calcium Regulation in Histamine-Challenged Cells.

Cells - 16 Jul 2024

Lecchi Giulia, Mocchetti Chiara, Tunesi Davide, Berto Arianna, Balasubramanian Hari Baskar, Biswas Sima, Bagchi Angshuman, Pollastro Federica, Fresu Luigia Grazia, Talmon Maria

Abstract excerpt

Bitter taste receptors (TAS2Rs) expressed in extraoral tissues represent a whole-body sensory system, whose role and mechanisms could be of interest for the identification of new therapeutic targets. It is known that TAS2R46s in pre-contracted airway smooth muscle cells increase mitochondrial calcium uptake, leading to bronchodilation, and that several SNPs have been identified in its gene sequence. There are...

Topics

Humans
Polymorphism, Single Nucleotide
Calcium
Receptors, G-Protein-Coupled
Histamine
Mitochondria
HEK293 Cells
Taste Receptors, Type 2

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39056786
DOI: 10.3390/cells13141204
PMCID: PMC11275237

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-39056786-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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