Human bitter perception correlates with bitter receptor messenger RNA expression in taste cells.

doi:10.3945/ajcn.113.066688

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Article

Human bitter perception correlates with bitter receptor messenger RNA expression in taste cells.

The American journal of clinical nutrition - 1 Oct 2013

Lipchock Sarah V, Mennella Julie A, Spielman Andrew I, Reed Danielle R

Abstract excerpt

BACKGROUND: Alleles of the receptor gene TAS2R38 are responsible in part for the variation in bitter taste perception of 6-n-propylthiouracil (PROP) and structurally similar compounds (eg, glucosinolates in cruciferous vegetables). At low concentrations, people with the PAV ("taster" amino acid sequence) form of TAS2R38 perceive these bitter compounds, whereas most with the AVI ("nontaster" amino acid sequence)...

Topics

Alleles
Beverages
Daucus carota
Diet
Feeding Behavior
Gene Expression
Glucosinolates
Heterozygote
Humans
Polymerase Chain Reaction
Propylthiouracil

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Messenger

Receptors, G-Protein-Coupled

Taste

Taste Buds

Taste Perception

Taste Receptors, Type 2

Source

Open in PubMed Open full text

Identifiers

PMID: 24025627
DOI: 10.3945/ajcn.113.066688
PMCID: PMC3778862

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-24025627-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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