Linkage and association of preserved cognitive function in the midwestern Amish at a higher genetic risk of Alzheimer's disease.

doi:10.1002/alz.70627

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Article

Linkage and association of preserved cognitive function in the midwestern Amish at a higher genetic risk of Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Aug 2025

Dorfsman Daniel A, Prough Michael B, Gulyayev Alex V, Caywood Laura J, Clouse Jason E, Herington Sharlene D, Slifer Susan H, Adams Larry D, Laux Renee A, Song Yeunjoo E, Lynn Audrey, Fuzzell Sarada L, Hochstetler Sherri D, Miskimen Kristy, Main Leighanne R, Wang Ping, Liu Yining, Moore Noel, Ogrocki Paula, Lerner Alan J, Vance Jeffery M, Cuccaro Michael L, Haines Jonathan L, Pericak-Vance Margaret A, Scott William K

Abstract excerpt

INTRODUCTION: Genetic factors promoting cognitive preservation in high-risk older adults for Alzheimer's disease (AD) risk remain understudied. Among Midwestern Amish with elevated AD genetic risk, we hypothesized ranking sibships by mean genetic risk scores during linkage analysis would reveal loci influencing preserved cognition. METHODS: We evaluated 1855 Amish adults (≥75 years) using the Modified Mini-Mental...

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PMID: 40855969
DOI: 10.1002/alz.70627
PMCID: PMC12378373

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KCNA5
NPL

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