Genetic analysis of cognitive preservation in the midwestern Amish reveals a novel locus on chromosome 2.

doi:10.1002/alz.14045

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Genetic analysis of cognitive preservation in the midwestern Amish reveals a novel locus on chromosome 2.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Nov 2024

Main Leighanne R, Song Yeunjoo E, Lynn Audrey, Laux Renee A, Miskimen Kristy L, Osterman Michael D, Cuccaro Michael L, Ogrocki Paula K, Lerner Alan J, Vance Jeffery M, Fuzzell Denise, Fuzzell Sarada L, Hochstetler Sherri D, Dorfsman Daniel A, Caywood Laura J, Prough Michael B, Adams Larry D, Clouse Jason E, Herington Sharlene D, Scott William K, Pericak-Vance Margaret A, Haines Jonathan L

Abstract excerpt

INTRODUCTION: Alzheimer's disease (AD) remains a debilitating condition with limited treatments and additional therapeutic targets needed. Identifying AD protective genetic loci may identify new targets and accelerate identification of therapeutic treatments. We examined a founder population to identify loci associated with cognitive preservation into advanced age. METHODS: Genome-wide association and linkage...

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PMID: 39376159
DOI: 10.1002/alz.14045
PMCID: PMC11567819

Genes

CTNNA2
POU3F2

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