Article
Combinatorial Mismatch Scan (CMS) for loci associated with dementia in the Amish.
BMC medical genetics - 3 Mar 2006
McCauley Jacob L, Hahs Daniel W, Jiang Lan, Scott William K, Welsh-Bohmer Kathleen A, Jackson Charles E, Vance Jeffery M, Pericak-Vance Margaret A, Haines Jonathan L
Abstract excerpt
BACKGROUND: Population heterogeneity may be a significant confounding factor hampering detection and verification of late onset Alzheimer's disease (LOAD) susceptibility genes. The Amish communities located in Indiana and Ohio are relatively isolated populations that may have increased power to detect disease susceptibility genes. METHODS: We recently performed a genome scan of dementia in this population that...
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