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Article

Psychometric approaches to defining cognitive phenotypes in the Old Order Amish.

International journal of geriatric psychiatry - 1 Apr 2023

Zaman Andrew, Caywood Laura, Prough Michael, Clouse Jason, Harrington Sharlene, Adams Larry, Fuzzell Denise, Fuzzell Sarada, Laux Renee, Hochstetler Sherri D, Ogrocki Paula, Lerner Alan, Vance Jeffery M, Haines Jonathan L, Scott William K, Pericak-Vance Margaret A, Cuccaro Michael L

Abstract excerpt

OBJECTIVE: Memory and cognitive problems are central to the diagnosis of Alzheimer's disease (AD). Psychometric approaches to defining phenotypes can aid in identify genetic variants associated with AD. However, these approaches have mostly been limited to affected individuals. Defining phenotypes of both affected and unaffected individuals may help identify genetic variants associated with both AD and healthy...

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PMID: 36929524
DOI: 10.1002/gps.5903

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