Article
A genome-wide linkage analysis of dementia in the Amish.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Mar 2006
Hahs Daniel W, McCauley Jacob L, Crunk Amy E, McFarland Lynne L, Gaskell Perry C, Jiang Lan, Slifer Susan H, Vance Jeffery M, Scott William K, Welsh-Bohmer Kathleen A, Johnson Stephanie R, Jackson Charles E, Pericak-Vance Margaret A, Haines Jonathan L
Abstract excerpt
Susceptibility genes for Alzheimer's disease are proving to be highly challenging to detect and verify. Population heterogeneity may be a significant confounding factor contributing to this difficulty. To increase the power for disease susceptibility gene detection, we conducted a genome-wide genetic linkage screen using individuals from the relatively isolated, genetically homogeneous, Amish population. Our...
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