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Article

Impact of PNPLA3 I148M on Drug-Induced Hepatocellular Liver Injury: A Systematic Review and Meta-Analysis.

Liver international : official journal of the International Association for the Study of the Liver - 1 Sept 2025

Gatzios Alexandra, Marchandise Lorna, Hagström Hannes, Schattenberg Jörn M, Rodrigues Robim M, Vanhaecke Tamara, Boeckmans Joost

Abstract excerpt

BACKGROUND AND AIMS: The role of the patatin-like phospholipase domain-containing protein 3 (PNPLA3)-I148M variant in drug-induced liver injury (DILI) remains unclear. This systematic review with meta-analysis investigated whether carriage of PNPLA3 I148M may contribute to the development of hepatocellular DILI. METHODS: Scientific databases were searched up to January 31st, 2025 for studies investigating serum...

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Identifiers

PMID: 40851509
DOI: 10.1111/liv.70287
PMCID: PMC12375943

Genes

PNPLA3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

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