Patatin-Like Phospholipase Domain-Containing Protein 3 rs2896019 and MASLD Susceptibility and Severity in Adults: A Systematic Review and Meta-Analysis of Case-Control Studies.

doi:10.1177/15578518261443934

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Patatin-Like Phospholipase Domain-Containing Protein 3 rs2896019 and MASLD Susceptibility and Severity in Adults: A Systematic Review and Meta-Analysis of Case-Control Studies.

Metabolic syndrome and related disorders - 1 Sept 2026

Lim Wei-Yue, Mohamed Rosmawati, Pung Yuh-Fen, Leung Hak-Keith, Ng Rong-Xiang, Zain Shamsul Mohd

Abstract excerpt

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading cause of global liver morbidity. Genetic variants, particularly in the patatin-like phospholipase domain-containing 3 (PNPLA3) gene, are critical determinants of metabolic traits and disease progression. This study presents the first meta-analysis to clarify the association between the PNPLA3 rs2896019 polymorphism and MASLD...

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PMID: 41995081
DOI: 10.1177/15578518261443934

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PNPLA3

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