Article
The causal relationship between steroid hormones and risk of stroke: evidence from a two-sample Mendelian randomization study.
Molecular brain - 23 Jan 2025
Zhang Yang, Jiang Miaowen, Wu Di, Li Ming, Ji Xunming
Abstract excerpt
It is unclear how steroid hormones contribute to stroke, and conducting randomized controlled trials to obtain related evidence is challenging. Therefore, Mendelian randomization (MR) technique was employed in this study to examine this association. Through genome-wide association meta-analysis, the genetic variants of steroid hormones, including testosterone/17β-estradiol (T/E2) ratio, aldosterone,...
Read the complete abstract on PubMedTopics
- Mendelian Randomization Analysis
- Humans
- Stroke
- Risk Factors
- Genome-Wide Association Study
- Steroids
- Genetic Predisposition to Disease